Genetics

Exploring the genetic overlap of suicide-related behaviors and substance use disorders.

S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.

Creation and evaluation of full-text literature-derived, feature-weighted disease models of genetically determined developmental disorders.

Sex significantly impacts the function of major depression-linked variants in vivo.

Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people.

Autism spectrum disorder/intellectual disability-associated mutations in trio disrupt neuroligin 1-mediated synaptogenesis.

Multivariate genome-wide covariance analyses of literacy, language and working memory skills reveal distinct etiologies.

Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes.

Interaction studies of risk proteins in human induced neurons reveal convergent biology and novel mechanisms underlying autism spectrum disorders.

Using brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia.

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