Exploiting genetics to identify environmental risks for autism
On 22 February 2017, Mark Zylka will describe how candidate environmental risk factors for autism can be identified rationally, by pinpointing chemicals that interfere with the same molecular pathways that are affected in individuals with autism.
His talk is part of the Simons Foundation Autism: Emerging Concepts lecture series.
The lecture will take place in the Gerald D. Fischbach Auditorium at the Simons Foundation headquarters (160 Fifth Avenue, New York, NY) and is open to the scientific community.
About the lecture:
Our inability to identify environmental threats to the brain early — before they cause disease — represents one of the major challenges of our time. This challenge is particularly relevant to autism, which affects 1 in 68 individuals. Heritability studies indicate that environmental factors contribute to autism risk.
In this lecture, Mark Zylka will describe how candidate environmental risk factors for autism can be identified rationally, by pinpointing chemicals that interfere with the same molecular pathways that are affected in individuals with autism. His research focuses on identifying environmental-use chemicals that target autism-linked molecular pathways, using environmental sampling data to assess the exposure threat to people, and validating risk potential in animal models.
About the speaker:
Mark Zylka is Director of the Neuroscience Center at the University of North Carolina at Chapel Hill. He received his B.S. in biochemistry from Virginia Polytechnic Institute and State University, and his Ph.D. in neurobiology from Harvard University. While at Harvard, he identified several of the core circadian-clock genes and determined how these genes contribute to circadian rhythms in mammals. As a postdoctoral fellow at the California Institute of Technology, he identified a large family of receptors that regulate pain and itch. Zylka’s lab focuses on pain research and studying genetic and environmental risks for autism.