Genetics

Gene regulatory control of prefrontal cortex development and evolution

Studying the development of the human midfetal prefrontal cortex (PFC) is integral to understanding the pathophysiology of ASD. Nenad Sestan aims to generate a multispecies comprehensive tissue-level and single-cell profile of the midfetal PFC to identify pertinent gene regulatory pathways and candidate genes. The function of identified ASD-relevant pathways will then be assessed in CRISPR-based targeted deletion/insertion mouse lines.

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