Guo-Li Ming, M.D., Ph.D.

Professor, University of Pennsylvania

SFARI Investigator, SFARI Scientific Review Board Website

Guo-li Ming is a professor of neuroscience at the Perelman School of Medicine, University of Pennsylvania. Her research is focused on understanding molecular mechanisms underlying normal neurodevelopment and how its dysregulation may contribute to developmental neurological disorders.

Her laboratory is interested in addressing a broad range of topics, from neuronal migration, axon and dendritic development, synapse formation, circuitry integration to plasticity of developing neurons and functional regeneration of mature neurons. Her group uses a combination of experimental approaches that span molecular, genetic, imaging and electrophysiology techniques in genetically modified mice and induced pluripotent stem cell (iPSC) lines derived from individuals with developmental neurological disorders.

Funded Projects

Mapping 3D genomic architecture in human developing neurons to assess the contribution of noncoding risk variants for autism

Awarded: 2016
Award Type: Pilot

SFARI Funded Publications

CYFIP1 dosages exhibit divergent behavioral impact via diametric regulation of NMDA receptor complex translation in mouse models of psychiatric disorders. Kim N.-S., Ringeling F.R., Zhou Y., Nguyen H.N., Temme S.J., Lin Y.-T., Eacker S., Dawson V.L., Dawson T., Xiao B., Hsu K.-S., Canzar S., Li W., Worley P., Christian K.M., Yoon K.-J., Song H., Ming G.

Robust Hi-C maps of enhancer-promoter interactions reveal the function of non-coding genome in neural development and diseases. Lu L., Liu X., Huang W.-K., Giusti-Rodríguez P., Cui J., Zhang S., Xu W., Wen Z., Ma S., Rosen J.D., Xu Z., Bartels C.F., Kawaguchi R., Hu M., Scacheri P.C., Rong Z., Li Y., Sullivan P.F., Song H., Ming G., Li Y., Jin F.

FMRP modulates neural differentiation through m⁶A-dependent mRNA nuclear export. Edens B.M., Vissers C., Su J., Arumugam S., Xu Z., Shi H., Miller N., Rojas Ringeling F., Ming G., He C., Song H., Ma Y.C.