SFARI | Search Results for “cra”

Altered hormone signaling in the brainstem causes motor delays in 16p11.2 mice

Simon Chen and colleagues found that a reduction in locus-coeruleus noradrenaline neuromodulatory signaling contributes to altered motor learning in 16p11.2 deletion mice.

Paul Tesar, Ph.D.

Tesar joined the faculty at CWRU in 2010 and is currently the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at CWRU School of Medicine. His laboratory has pioneered new regenerative approaches to treat myelin disorders of the central nervous system, including multiple sclerosis, neuromyelitis optica, pediatric leukodystrophies, cerebral palsy and brain cancer.

Bridge to Independence Award Fellows

Phenotyping sleep

Emmanuel Mignot discussed sleep biology as well as sleep disorders and their impact. He presented a link to what is known on the genetics of sleep and sleep disorders. He emphasized the need for large scale objective sleep recording studies with genomic and proteomic analysis to better understand the molecular pathways regulating sleep and circadian biology.

Transgenerational mitochondrial mutations in autism spectrum disorder

The mitochondrial genome encodes genes critical for energy production within the brain. Many lines of evidence suggest that mitochondrial function may be impaired in autism. Neal Sondheimer will evaluate the association between mitochondrial mutations and their interactions with the nuclear genome and the risk for autism.

Neuronal activity-dependent chromatin remodeling in autism

Neuronal activity triggers the expression of new genes that play a critical role in aspects of neural development and cognitive function. Building on evidence suggesting links between a class of ASD susceptibility loci (i.e., subunits of the BAF chromatin remodeling complex) and this form of gene regulation, Michael Greenberg and colleagues seek to determine whether disruption in neuronal activity-responsive chromatin remodeling underlies the effects of these ASD mutations.

De novo truncating variants in the AHDC1 gene encoding the AT-hook DNA-binding motif-containing protein 1 are associated with intellectual disability and developmental delay.

Beta2-adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome.

A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism.

miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity.