Liqun Luo uses conditional, cell-type-specific RAI1 deletions in mice to assess how loss of RAI1 contributes to neurodevelopmental phenotypes in Smith-Magenis syndrome.
New genetic variants that increase susceptibility to autism are emerging at a rapid pace. Given the profusion of data, it seems timely to assess the availability and usefulness of mouse models in which to study these genetic risk factors.
Researchers can use biomarkers to diagnose individuals with autism and to hone in on the underlying causes of the disorder. In July, SFARI held an informal meeting of minds at Stony Brook University to discuss biomarkers for autism.
Researchers need reliable methods to interpret autism candidate genes, including rodent models to assess the impact of genes on behavior. On 4 February, SFARI hosted a workshop to discuss the role of mouse models and behavioral assays in autism research. The participants concluded that the field should invest in techniques that can be standardized across laboratories and emphasized the importance of mouse models for identifying biomarkers and testing therapies.
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