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SFARI Base

SFARI Base is a central database of clinical and genetic information about families affected by autism and other neurodevelopmental disorders, provided as part of the Simons Foundation Autism Research Initiative (SFARI). The database contains phenotype data from the Simons Simplex Collection and the Simons Variation in Individuals Project, and some individuals within the collections provide biospecimens, imaging data and the opportunity to contact them for additional research.

SFARI Base

SIMONS SIMPLEX COLLECTION

SIMONS VARIATION IN INDIVIDUALS PROJECT

About SSC
About Simons VIP

The Simons Simplex Collection (SSC) is a rigorously characterized sample of 2,644 simplex families, each of which has only one individual with an autism spectrum disorder. In addition to the wide variety of clinical data available on affected participants and unaffected parents and siblings, various biospecimens have also been collected and subsequently derived. These are available through RUCDR Infinite Biologics (formerly Rutgers University Cell and DNA Repository). Approximately 400 families who participated in the SSC have agreed to be recontacted for additional studies. This process is facilitated by [email protected] and is described in the document below.

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Simons VIP uses a genetics-first approach to data collected from a large number of individuals with specific genetic variations that increase the risk of developing autism spectrum and other developmental disorders. In addition to information on roughly 300 individuals with either a deletion or a duplication of chromosomal region 16p11.2, the collection contains information on over 60 individuals with a 1q21.1 deletion or duplication. The collection has recently been expanded to include individuals with mutations in 47 single genes associated with neurodevelopmental differences and features of autism; data on 7 individuals with GRIN2B mutations and 11 individuals with SCN2A mutations are currently available in SFARI Base.

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Access SFARI resources

Before you can access genetic, phenotypic, or imaging data, biospecimens, or recontact participants, you must complete an application. The application procedure is:

If you have questions or issues during this process, please contact [email protected].

Review protocols

All information related to phenotype data and biological materials has been coded so that subjects cannot be directly identified.

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