Kasper Lage, Ph.D.

Associate Professor, Harvard Medical School
Director of Bioinformatics, Massachusetts General Hospital
Associate Member, Stanley Center for Psychiatric Research, Broad Institute

SFARI Investigator, SFARI Scientific Review Board Website

Kasper Lage is director of bioinformatics of the Massachusetts General Hospital and an associate professor at Harvard Medical School. He is also a group leader and member of the leadership group of the Stanley Center for Psychiatric Research at the Broad Institute.

His group has contributed several technologies, algorithms and web platforms that are widely used to interpret genomic data, and his work has led to the identification of specific genes and networks involved in metabolic, psychiatric, neurodevelopmental, reproductive and cardiovascular disorders.

Lage serves on the Research Computation Oversight Committee of Partners Healthcare, and he was the Harvard University Principal Investigator of the Functional Interpretation Group of the 1000 Genomes Project.

Funded Projects

Defining the regulatory landscape of autism susceptibility genes in human neurons

Awarded: 2020
Award Type: Pilot

Brain protein networks perturbed by autism risk genes

Awarded: 2017
Award Type: Research

SFARI Funded Publications

Using brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia. Hsu Y.-H.H., Nacu E., Liu R., Kim A., Tsafou K., Petrossian N., Crotty W., Suh J.M., Pintacuda G., Riseman J., Martín J.M., Malolepsza E., Li T., Singh T., Ge T., Egri S.B., Tanenbaum B., Stanclift C.R., Apffel A.M., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Carr S.A., Schenone M., Jaffe J., Fornelos N., Huang H., Eggan K. C., Lage K.

Interaction studies of risk proteins in human induced neurons reveal convergent biology and novel mechanisms underlying autism spectrum disorders. Pintacuda G., Hsu Y.-H.H., Tsafou K., Li K.W., Martín J.M., Riseman J., Gonzalez-Lozano M.A., Egri S.B., Jaffe J., Smit A., Fornelos N., Eggan K. C., Lage K.

Systematic multi-trait AAV capsid engineering for efficient gene delivery. Eid F.-E., Chen A.T., Chan K.Y., Huang Q., Zheng Q., Tobey I.G., Pacouret S., Brauer P.P., Keyes C., Powell M., Johnston J., Zhao B., Lage K., Tarantal A.F., Chan Y.A., Deverman B.E.