Ype Elgersma, Ph.D.

Professor, Erasmus University Medical Center

SFARI Investigator, SFARI Scientific Review Board Website

Ype Elgersma is a professor at the Erasmus University Medical Center in Rotterdam, and the scientific director of the ENCORE Expertise Centre for Neurodevelopmental Disorders. His laboratory focuses on molecular and cellular mechanisms underlying neurodevelopmental disorders, including autism and Angelman syndrome.

Funded Projects

The role of UBE3A in autism: Is there a critical window for social development?

Awarded: 2013
Award Type: Pilot

SFARI Funded Publications

De novo variants in the PSMC3 proteasome AAA-ATPase subunit gene cause neurodevelopmental disorders associated with type I interferonopathies. Ebstein F., Küry S., Most V., Rosenfelt C., Scott-Boyer M.-P., van Woerden G.M., Besnard T., Papendorf J.J., Studencka-Turski M., Wang T., Hsieh T.-C., Golnik R., Baldridge D., Forster C., de Konink C., Teurlings S.M.W., Vignard V., van Jaarsveld R.H., Ades L., Cogné B., Mignot C., Deb W., Jongmans M.C.J., Cole F.S., van den Boogaard M.-J.H., Wambach J.A., Wegner D.J., Yang S., Hannig V., Brault J.A., Zadeh N., Bennetts B., Keren B., Gélineau A.-C., Powis Z., Towne M., Bachman K., Seeley A., Beck A.E., Morrison J., Westman R., Averill K., Brunet T., Haasters J., Carter M.T., Osmond M., Wheeler P.G., Forzano F., Mohammed S., Trakadis Y., Accogli A., Harrison R., Deciphering Developmental Disorders Study, Care4Rare Canada Consortium, Rondeau S., Baujat G., Barcia G., Feichtinger R.G., Mayr J.A., Preisel M., Laumonnier F., Knaus A., Isidor B., Krawitz P., Völker U., Hammer E., Droit A., Eichler E., Elgersma Y., Hildebrand P.W., Bolduc F., Krüeger E., Bézieau S.

Adult Ube3a gene reinstatement restores the electrophysiological deficits of prefrontal cortex layer 5 neurons in a mouse model of Angelman syndrome. Rotaru D.C., van Woerden G.M., Wallaard I., Elgersma Y.

UBE3A loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice. Wallace M.L., van Woerden G.M., Elgersma Y., Smith S.L., Philpot B.