Jordane Dimidschstein, Ph.D.

Group Leader and Research Scientist, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard

SFARI Investigator Website

Jordane Dimidschstein is a group leader and research scientist in the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, where he develops methods to target and manipulate specific neuronal populations across species, including nonhuman primates. Overall, his research focuses on studying the contribution of specific neuronal populations to normal brain function and, conversely, how alteration of their function can lead to neurodevelopmental disorders such as autism, schizophrenia and bipolar disorders.

Dimidschstein received his master’s degree in biological sciences from the University of Liège. He holds an additional master’s degree in health science and a Ph.D. in neuroscience from the University of Brussels, where he studied key aspects of neuronal migration during cortical development. He completed his postdoctoral training at New York University School of Medicine where he developed a novel viral strategy to target and manipulate interneurons across vertebrate species.

Funded Projects

Identification of developmental subcortical vulnerabilities in autism spectrum disorder

Awarded: 2018
Award Type: Research

SFARI Funded Publications

Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s. Oláh V.J., Goettemoeller A.M., Rayaprolu S., Dammer E.B., Seyfried N.T., Rangaraju S., Dimidschstein J., Rowan M.J.M.

Alternating sources of perisomatic inhibition during behavior. Dudok B., Klein P.M., Hwaun E., Lee B.R., Yao Z., Fong O., Bowler J.C., Terada S., Sparks F.T., Szabo G.G., Farrell J.S., Berg J., Daigle T.L., Tasic B., Dimidschstein J., Fishell G., Losonczy A., Zeng H., Soltesz I.

Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans. Vormstein-Schneider D.C., Lin J.D., Pelkey K.A., Chittajallu R., Guo B., Arias-Garcia M.A., Allaway K., Sakopoulos S., Schneider G., Stevenson O., Vergara J., Sharma J., Zhang Q., Franken T.P., Smith J., Ibrahim L.A., Astro K.J.M., Sabri E., Huang S., Favuzzi E., Burbridge T., Xu Q., Guo L., Vogel I., Sanchez V., Saldi G.A., Gorissen B.L., Yuan X., Zaghloul K.A., Favuzzi E., Devinsky O., Sabatini B., Batista-Brito R., Reynolds J., Feng G., Fu Z., McBain C.J., Fishell G., Dimidschstein J.