Jonathan Mill, Ph.D.

Professor, University of Exeter

SFARI Investigator Website

Jonathan Mill is professor of epigenomics at the University of Exeter Medical School, UK. He graduated with a first-class degree in human sciences from Oxford University, before undertaking his Ph.D. in psychiatric genetics at the Institute of Psychiatry, King’s College London. After spending three years as a Canadian Institutes of Health Research postdoctoral fellow at the University of Toronto, he returned to the Institute of Psychiatry to establish the Psychiatric Epigenetics group in the MRC Social, Genetic and Developmental Psychiatry Centre in 2007. He joined the University of Exeter Medical School in 2012 to head the Complex Disease Epigenomics Group.

Mill’s research focuses on understanding both the causes and consequences of molecular variation in the human brain and the role this plays in neuropsychiatric and neurodegenerative disorders including autism, schizophrenia and dementia. His group is interested in the dynamic genomic processes occurring in human brain development and aging, exploring interactions between the epigenome, environment and DNA sequence variation. Using cutting-edge genomics methods, their aim is to undertake an integrated genetic-epigenetic approach to disease, incorporating genetic, transcriptional and epigenomic variation.

Funded Projects

Exploring regulatory genomic variation in the developing human brain to understand autism

Awarded: 2018
Award Type: Research

SFARI Funded Publications

Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing. Leung S.K., Jeffries A.R., Castanho I., Jordan B.T., Moore K., Davies J.P., Dempster E.L., 4 N.J.B., O'Neill P., Tseng E., Ahmed Z., Collier D.A., Jeffery E.D., Prabhakar S., Schalkwyk L., Jops C., Gandal M., Sheynkman G.M., Hannon E., Mill J.

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Steg L.C., Shireby G.L., Imm J., Davies J.P., Franklin A., Flynn R., Namboori S.C., Bhinge A., Jeffries A.R., Burrage J., Neilson G.W.A., Walker E.M., Perfect L.W., Price J., McAlonan G., Srivastava D. P., Bray N.J., Cope E.L., Jones K.M., Allen N.D., Pishva E., Dempster E.L., Lunnon K., Mill J., Hannon E.

Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism. Ramaswami G., Won H., Gandal M., Haney J., Wang J.C., Wong C.C.Y., Sun W., Prabhakar S., Mill J., Geschwind D.