Method pinpoints cell-specific effects of autism-linked mutations
The approach, which combines CRISPR with single-cell analyses of organoids, suggests that intermediate progenitor cells are especially vulnerable to mutations associated with autism.
Emerging tools and techniques that may advance autism research.
The tool — called “MouseGoggles” — could provide rodents with an improved virtual experience in the lab, at a lower cost than current techniques.
The approach, which combines CRISPR with single-cell analyses of organoids, suggests that intermediate progenitor cells are especially vulnerable to mutations associated with autism.
A thin “micro-tether” and rotating connector facilitate uninterrupted, hours-long neural population recordings as the animals freely explore their environment.
A new tool could help decipher the brain circuits underlying aversion to social touch, which is common in people with autism.
The new devices, which monitor neural activity from within blood vessels, show long-term stability in rats and could one day deliver electrical stimulation.
Over one hour, a particularly motivated mouse poked its nose 350 times into a hole in the test chamber in the hopes of meeting a playmate.
The map, by far the largest one of an entire brain to date, contains 130,000 neurons and 53 million synapses.
The tool could help researchers study the neurobiology of natural behaviors, scientists say.
The newfound DNA-cutting enzyme, called Fanzor, can be programmed to edit the human genome and could prove easier to deliver to cells than current CRISPR tools.
A new resource gives an unparalleled look at how fetal placental cells attach to the uterine wall and remodel maternal blood vessels to access nutrients.
When combined with tissue-inflation methods, the microscope can image axons without the need for tissue slicing, the researchers say.