New zebrafish lines with mutations in high-confidence autism risk genes DYRK1A and GRIN2B have been added to SFARI resources. The two models are the latest additions to the various zebrafish lines currently curated by SFARI.

To date, SFARI has curated zebrafish lines for genes ARID1B, CHD8, DYNC1H1, FMR1, MECP2, MEFC2, PTEN and SCN1A/SCN2A. Along with the recently introduced lines for DYRK1A and GRIN2B, additional zebrafish models with mutations in CNTNAP2, NRXN1, SHANK3 and SYNGAP1 will be made available in 2023. These models are curated with the goal of facilitating research into the biological mechanisms underlying mutations linked to autism and potential therapeutic targets.

All zebrafish models curated by SFARI have been validated by directly measuring mRNA or protein levels (where antibodies are available) rather than by assessing phenotype. These lines are deposited in the Zebrafish International Resource Center (ZIRC). Investigators interested in using these zebrafish models for their research should contact ZIRC for additional information.

For general information regarding SFARI’s experimental models, please contact models@simonsfoundation.org.