Tag: autism

  • Apples and oranges: When identifying human emotions, individuals with fragile X show increased activation in the left hippocampus (B) and the right insula (C), compared with people who have autism.
    news

    Autism and fragile X syndrome are characterized by very different brain processes, even though the two disorders show similar social deficits, say authors of the first functional imaging study to compare the two disorders1.

    Fragile X syndrome is a form of inherited mental retardation that stems from a rare mutation in...

    23 Dec 2008 .:. 0 comments
  • Coping trouble: Mice that lack FKBP12 in their brains late in development have difficulty learning new ways to solve a task.
    news

    The absence of a protein involved in a prominent cancer pathway leads to repetitive behaviors and learning deficits in mice, creating a viable model for autism research, according to a study published last week in Neuron 1.

    The protein, FKBP12, serves as a receptor for rapamycin, a cancer drug that has...

    17 Dec 2008 .:. 0 comments
  • Exclusive expression: In the human fetal brain, the highest levels of CNTNAP2 in the cerebral cortex are seen between bands of FOXP2 expression. FOXP2 is present at high levels in the molecular zone, deep layers of the cortical plate, and subplate (subpanel b).
    news

    Variants in contactin-associated protein-like 2 or CNTNAP2 — a gene thought to be involved in nerve cell communication — are associated with language deficits in families affected by specific language impairment (SLI), a developmental disorder that affects roughly seven percent of kindergarten-age children, according to a study published in late November...

    12 Dec 2008 .:. 0 comments
  • Cumulative effect: For children with autism, even a delay of 50 milliseconds in processing sound could translate to serious problems with language and communication.
    news

    Children with autism process sounds a split second slower than typically developing children, according to a new study that measured the magnetic fields emitted from the children's brains.

    Although preliminary, the findings may partly explain the language and communication problems that burden so many with the disorder, the researchers say.

    "The findings [show...

    09 Dec 2008 .:. 0 comments
  • Puzzling results: Duplication of a region on chromosome 15 has different effects in different people.
    news

    The first postmortem study to examine the effects of chromosome 15 duplication on gene expression shows completely divergent results, suggesting that the effect of genetic duplications is far from predictable, according to a study published last month in the Journal of Medical Genetics 1.

    Between 1 to 3 percent of people...

    03 Dec 2008 .:. 0 comments
  • Micro effects: Representative microRNAs are  differentially expressed in a 6-year-old (left), an 11-year-old (center) and a 13-year-old, all with autism and compared with age-matched controls. Up-regulated miRNAs are in red and down-regulated ones in green.
    news

    Some small fragments of RNA are expressed differently in people with autism than in controls, according to two new studies. The findings unveil another layer of complexity in the genetics of autism.

    These pieces of single-stranded RNA — dubbed microRNAs or miRNAs — have wide-ranging, subtle effects on the production of many...

    26 Nov 2008 .:. 0 comments
  • Speaking volumes: Manually defining amygdala borders, scientists have found that the larger the size of the region, the worse a child's language ability.
    conference report

    A child's language ability correlates with the volume of his or her amygdala — the small, deep brain region that is strongly associated with emotional processing — according to an unpublished five-year longitudinal study presented Wednesday afternoon at the Society for Neuroscience meeting.

    Analyzing brain imaging data collected from 24 infants at...

    21 Nov 2008 .:. 0 comments
  • How do I ape thee: Children with autism rely on 'action-constrained' neurons to perceive others' actions, scientists say.
    conference report

    High-functioning children with autism may understand another person’s intention when, for example, that person reaches for a glass of water — a simple, goal-directed task — without help from the mirror neuron system, according to research reported Tuesday at the Society for Neuroscience meeting.

    Some researchers have proposed that mirror neurons —...

    20 Nov 2008 .:. 0 comments
  • On target: Researchers are studying mouse retinas to uncover the genes that help neurons find their synaptic partners.
    conference report

    Researchers are narrowing in on a pool of genes that may be involved in helping neurons find their targets, according to unpublished work presented today in a poster session at the Society for Neuroscience meeting.

    The work focused on neurons in the mouse retina, the inner layer of the eye, but has...

    19 Nov 2008 .:. 0 comments
  • Dopamine drug: Risperidone is used to treat irritability in children and adolescents with autism.
    conference report

    A new slow-release form of the drug risperidone — an antipsychotic given to people with schizophrenia, autism and other psychiatric conditions — lasts in the blood days instead of hours, according to research presented today at the Society for Neuroscience meeting.

    Risperidone inhibits dopamine signaling in the brain, and the U.S. Food...

    19 Nov 2008 .:. 0 comments