SFARI Initiatives
Simons Simplex Collection
The Simons Simplex Collection (SSC) is a core project and resource of the Simons Foundation Autism Research Initiative (SFARI). The SSC established a permanent repository of genetic samples from 2,700 families, each of which has one child affected with an autism spectrum disorder, and unaffected parents and siblings. Each genetic sample has an associated collection of data that provides a precise characterization of the individual (phenotype). Rigorous phenotyping maximizes the value of the resource for a wide variety of future research projects on the causes and mechanisms of autism.
Simons VIP
The Simons Variation in Individuals Project (Simons VIP) is a new research initiative that aims to identify and study a large number of individuals with a recurrent genetic variation (deletion or duplication of segment 16p11.2) that increases the risk of developing autism spectrum and other neurodevelopmental disorders. The Simons VIP will collect detailed clinical information and blood samples from more than 200 families, with the immediate goal of identifying medical, cognitive, neural and behavioral profiles shared by this genetically identified group. De-identified participant data and biospecimens will be available to qualified researchers worldwide. Careful analysis of genetically defined autism subtypes will allow detailed phenotypic comparisons within and among these groups to clarify genotype-phenotype correlations. Longer-term goals are to use these data to improve the quality of clinical care and to develop targeted interventions for individuals with autism.
