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In Brief

  • Genetics: Gene variants can predict autism severity
    19 August 2011
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    Children with autism who carry a certain variant of a protein involved in inhibitory signaling have more severe symptoms than those with another variant of the same gene, according to a study published 24 July in the Journal of Autism and Developmental Disorders.

  • Molecular mechanisms: MeCP2 regulated by chemical switch
    17 August 2011
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    MeCP2, the protein missing in people with Rett syndrome, enhances learning and memory by binding to key genes and either activating or inhibiting their expression, according to a study published 17 July in Nature Neuroscience. Adding a phosphate to the protein in response to neuronal activity releases MeCP2 from these genes, the study found.

  • Cognition and behavior: Response to emotions linked to autism
    16 August 2011
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    The brains of teenagers with autism and their unaffected siblings respond similarly to both happy and neutral faces, whereas those of controls seem to prefer happy ones, according to a study published 12 July in Translational Psychiatry.

  • Clinical research: Lack of gestures is specific to autism
    12 August 2011
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    Toddlers with autism are less likely to use gestures to communicate than are typically developing children and those with developmental delay or specific language impairment.

  • Genetics: Variants linked to autism-related behavior
    10 August 2011
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    Genetic variants in two autism-associated genes have been linked to repetitive behavior and hyperactivity, two common symptoms of the disorder, according to two studies published in the past few months.

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Connectivity

This special report examines the theory that neural connectivity is altered in autism, exploring the latest findings and debates in the field.