2010

  • Genetics: Gene interaction map reveals disease response
    21 December 2010
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    The pattern of interactions among different genes in yeast cells changes in response to disease-like conditions, in this case a DNA-damaging agent, according to a study published 3 December in Science. Mapping epistasis — how various cellular factors work together — is key to understanding complex disorders, such as autism.
  • Genetics: Gene that controls methylation linked to autism
    17 December 2010
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    A gene involved in epigenetics — regulation of gene expression by modifying DNA, but without altering the sequence — is associated with autism in families that have only one child with the disorder, according to a study published in November.
  • Cognition and behavior: Vocabulary similar in autism, language delay
    15 December 2010
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    Toddlers with autism take longer to build their vocabulary than do those who have only language impairment, according to a study published online in November. When matched by vocabulary level, however, the two groups use the same types of words and have the same grammatical skills.
  • Molecular mechanisms: Imaging technique reveals brain's diversity
    14 December 2010
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    A new technique called array tomography allows researchers to visualize individual synapses, the complex junctions between neurons, in the mouse brain. Researchers have also identified several markers that highlight the incredible diversity of synapse types.
  • Clinical research: Chromosome deletion linked to autism features
    13 December 2010
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    Individuals with a deletion in the 16p11.2 chromosomal region — which has been linked to autism in several studies — show features of autism spectrum disorders including language delay, according to a study published in October.
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New RFAs

SFARI has two new targeted RFAs, one on circuit dynamics and one on Simons VIP biospecimens.

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Connectivity

This special report examines the theory that neural connectivity is altered in autism, exploring the latest findings and debates in the field.