Dairy-free diets
Among many parents of children with autism, food free from wheat and dairy is considered one of the most effective ways to improve the symptoms of autism ― despite little solid evidence to support that claim.
Given the dietʼs popularity, though, itʼs clear that whatʼs needed are studies that look rigorously at the effects of the diet on children with autism to settle the matter one way or another.
Earlier this month, researchers at the University of Texas Health Science Center in Houston set out to do exactly that. They plan to enroll 38 children with autism ranging in age from 3 to 9 years, all of whom will get a gluten- and dairy-free diet before the study.
During the four weeks of the study itself, half of the children will be given gluten and milk powder, and half given a placebo powder. The researchers will then assess the childrenʼs urine for gastrointestinal changes, and their behavior with standard tests.
The premise underlying the special diet is that gluten, a protein found in wheat, and casein and whey, proteins found in milk, escape from the gut and enter the brain, where they trigger autism-like behaviors. This ‘leakyʼ gut hypothesis is becoming increasingly popular among some scientists, who say it may play a role in at least a small subset of children with autism.




Comments
There are a number of possible reasons why a casein and gluten free diet could have beneficial effects if these were seen in this study. One possibility is the opioid-leaky gut idea mentioned here.
For example, removing dairy and wheat bsed products from the diet cuts carbohydrate intake ++ and could lead to ketosis. A the ketogenic diet is successful in a significant proportion of epileptic cases and the prevalence of epilepsy is high in ASD, this might be the link.
I think the most interesting part of this research may be the comparison of differences betwen the reponders and non-responders to diet, as this could highlight endophenotypic variations of clinical importance.
As with so much in the ASD area, within group difference seems more likely to be important than commonality.