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DSM5.jpg: Updated guidelines: Asperger syndrome, autism and pervasive developmental disorder not otherwise specified will be combined into one diagnosis — autism spectrum disorder — in the new DSM-5.
Biomarkers-Article.jpg: U. of Washington Institute for Learning & Brain Sciences Inside information: Non-invasive techniques that measure electrical and magnetic activity within the brain promise to deliver diagnostic biomarkers for autism.
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Mouse-Models-in-Autism-Article.jpg: M. Yang Meet and greet: Social mice interact by sniffing each other, a behavior that is less common in mouse models of autism.
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Rapin-Article.jpg: Full physical: Clinicians should test children for hearing impairments before they diagnose them with with autism, cautions Isabelle Rapin.
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Abrahams-Article.jpg: Human genome: New technology that allows relatively inexpensive sequencing of large stretches of DNA will help researchers solve complex genetic disorders such as autism.
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Hagerman-Article.jpg: Signaling success: Dynamic changes in pupil size are often abnormal in people with fragile X syndrome, and can be used to assess the effectiveness of therapies.
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Dobkins-Article.jpg: First signs: The siblings of children who have autism are up to 20 times more likely than the general population to have the disorder.
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Philpot-Angelman-Article2.jpg: Similar symptoms: Angelman syndrome is caused by a deletion in the same genomic region that is affected in some cases of autism.
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Walsh-Article.jpg: Cultural potential: Genetic studies in countries where cousin marriages are common can uncover new autism genes.
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tager flusberg tom: Ann Senghas, 2004 Spontaneous gestures: Nicaraguan sign language, which evolved naturally from the 1970s, is an example of how language can create mind-blindness.
fair representation lauren weiss: Unequal chances: Up to five times more males than females have autism, and girls are also underrepresented in studies of the disorder.
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haze sive zebra fish: Developmental window: Zebrafish embryos are transparent, allowing researchers to label the brain with a dye and study its function in the live animal.
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sinha viewpoint: At first sight: The charitable organization Project Prakash provides sight-restoring surgeries to blind children in India, allowing researchers to study visual development.
lupski article: Click to enlarge Polar opposites: Two regions in the human genome lead to contrasting physical and behavioral effects, depending on whether they are deleted or duplicated.
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miles article: Facial identity: Unusual physical features, such as wide-set eyes, are more common in children with autism than in controls.
grandin sensory article: Sensory overload: Some children with autism love to push the cart in the grocery store, but others cannot stand the loud noises and flickering lights.
volkmar lessons learned: Teacher's time: As part of an effort to translate the findings of autism research, Fred Volkmar teaches an undergraduate seminar on autism at Yale University.
cnv alan packer: Image courtesy: Nature Genetics Closing in: New tools such as Canary may help find copy number variations that are valid and reproducible.
eric kandel viewpoint image: On track: Neuroscientist Eric Kandel is using a reductionist approach to study the underpinnings of autism.
hu viewpoint brain image: Simple solution: Blood can substitute for brain tissue in some studies of gene expression in autism.
charman viewpoint image: Facing forward: When Tony Charman first began studying autism in the 1980s, long-term studies of individuals with autism were rare.
nigg article image: Restful signals: Individuals with attention deficit hyperactivity disorder (middle) and autism (bottom) both show atypical activity in some of the same brain regions (blue circles) compared with controls (top).
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diamond viewpoint image: Self destruction: Antibodies carried in the blood of mothers of children with autism (top), but not those of mothers of typically developing children (bottom) attack proteins in mouse brains.
greenspan flies article image: Following flies: When fruit flies enter an enclosure, they explore their new environment and then cluster around a food source, whereas a second group of flies immediately joins the others.
bernier asd severity article image: Missing measure: Should the severity of autism be defined by the intensity of a person's symptoms or by his or her ability to function with them?
pelphrey article image: Diagnostic pattern: Children with Childhood Disintegrative Disorder have severe loss of skills after 2 years of age, leading to symptoms of autism such as repetitive behaviors.
schultz viewpoint article image: N. Price Ducks in a row: Children with autism may derive less reward from social interactions and more from non-social objects than their typically developing peers.
fombonne headshot image qa: Nebulous numbers: Eric Fombonne says the new CDC report does not necessarily mean that autism prevalence is increasing.
fombonne graph new: Click to enlarge image CDC Vast variability: There is a more than four-fold difference between the prevalence of autism in Alabama, which has the lowest rate, and Utah, which has the highest. The U.S. average rate is highlighted in red. States that used only health records (green) tend to have lower rates than those that used both health and educational records (blue).
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fombonne figure 2 new: Click to enlarge image CDC Margin of error: The states with the highest prevalence, Utah and New Jersey, also have the widest error bars because of their small sample sizes. States that used only medical records to assess prevalence (open circles) tend to have lower rates than those that used both medical and education records (filled circles).
fombonne figure 2 new new: Click to enlarge image CDC Margin of error: The states with the highest prevalence, Utah and New Jersey, also have the widest error bars because of their small sample sizes. States that used only medical records to assess prevalence (open circles) tend to have lower rates than those that used both medical and education records (filled circles).
kim viewpoint article image: Full picture: Screening a representative sample of all children in South Korea yielded an autism prevalence that is more than twice the rate in the U.S.
qa luca santarelli headshot: Matching compounds: Luca Santarelli says an important part of drug development for autism will be pairing the right drug with the right child.
chakravarti viewpoint article image: Hidden links: To identify rare mutations in complex disorders, researchers may need to screen the genomes of thousands of individuals.
sohal article image: Brain map: In the mouse prefrontal cortex, neurons that activate signals (green) form circuits with those that inhibit signals (red).
sahin viewpoint article image: Genetic risk: Mustafa Sahin studies tuberous sclerosis, a rare genetic disorder that leads to autism in about half of the cases.
sahin article embed image: Abnormal connections: Neurons lacking the TSC1 gene (above) have abnormal shapes and denser branches than do controls (top).
lasalle article collage viewpoint: Close contact: Exposure to certain environmental agents, such as chemicals found in plastics, may alter the expression of autism-related genes.
BrainBank-viewpoint: Rare resource: There are massive logistical challenges involved in research using postmortem brains, but the samples can substantially increase the power of studies.
VP-williams-syndrome-bicycle: Broken bike: Children with Williams syndrome have trouble understanding how different parts make up a whole object, such as a bicycle.
121016-viewpoint-mri: Limited resource: Brain imaging studies are typically small, making them good candidates for open-science projects that pool data.
20121113vpsc: Brain tales: Postmortem samples from well-characterized individuals with autism can help researchers distinguish causes and consequences of the disorder.
20121113vpscB: Brain tales: Postmortem samples from well-characterized individuals with autism can help researchers distinguish causes and consequences of the disorder.
20121127vpautismlanguage: Category change: The evolving guidelines for diagnosing autism acknowledge that when language is present in individuals on the autism spectrum, it may be atypical in subtle but important ways.
20121211vpwomenscience: Unequal opportunity: Evaluators subconsciously apply more stringent standards to a female scientific candidate than to a male candidate with the identical résumé.
20121211vpchart: Click to enlarge image Changing demographics: At the Massachusetts Institute of Technology, the proportion of women undergraduates, graduate students, postdoctoral scholars and faculty has risen dramatically since 1901.

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